Pesquisa sobre: DNA GYRASE 
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Descritor Inglês:   DNA Gyrase 
Descritor Espanhol:   ADN girasa 
Descritor Português:   DNA Girase 
Sinônimos Inglês:   DNA Gyrase A Subunit
DNA Gyrase B Subunit
DNA-Gyrase
GyrA Protein
GyrB Protein  
Categoria:   D08.811.399.403.741.149
D12.776.097.237
Definição Inglês:   A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Gyrase binds to DNA as a heterotetramer consisting of two A and two B subunits. In the presence of ATP, gyrase is able to convert the relaxed circular DNA duplex into a superhelix. In the absence of ATP, supercoiled DNA is relaxed by DNA gyrase. 
Combinados Inglês:   DNA Gyrase/antagonists & inhibitors use Topoisomerase II Inhibitors
 
Nota Histórica Inglês:   2002; use DNA TOPOISOMERASE (ATP-HYDROLYZING) 1994-2001, use DNA GYRASE 1980-1993; for GYRA PROTEIN use DNA TOPOISOMERASE (ATP-HYDROLYZING) (NM) 1992-2001; GYRB PROTEIN use DNA TOPOISOMERASE (ATP-HYDROLYZING) (NM) 1991-2001 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número do Registro:   36089 
Identificador Único:   D027081 

Ocorrência na BVS:
 

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